The characteristics of pharmaceutical powder sub-packaging machine and the reasons that affect the packaging error

The powder packing machine is to quantitatively pack sterile powder medicines into glass bottles that have been dried by bacteria, and seal them with rubber stoppers. The medicine is packaged in a sterile room at a constant temperature (20±2) ℃, a certain relative temperature (45%~60%), and the cleanliness is less than or equal to 10,000 grades. Powder packing machine can be divided into air packing machine and screw packing machine according to its structure type. Here we only introduce the powder packing machine in detail. The principle of airflow sub-packaging is to use vacuum to absorb a quantitative volume of powder, and then purify and dry the compressed air to eat the powder into a glass bottle. The characteristics of airflow sub-packaging are that the diameter of the powder blocks formed in the powder cavity is large, the filling speed is fast, generally up to 300~400 bottles/min, the filling accuracy is high, and the degree of automation is high. Therefore, this sub-packaging principle can be obtained. widely used. In the 1960s, foreign countries began to develop gas-liquid separators, and they gradually became serialized. After China introduced and digested the technology of the country, it only began to produce gas-liquid separators in the 1980s. The gas-liquid filling machine consists of the following parts: powder filling system, cap rubber stopper mechanism, body and main drive system, bottle conveying turntable mechanism, vacuum system, compressed air system, electrical control system and air purification control system. The powder dispensing system is an important part of the airflow dispensing mechanism. Its function is to hold the powder. The powder is quantified through the stirring and dispensing head, and it is periodically and neatly dispensed into the bottle with the assistance of vacuum and compressed air. It is composed of powder drum, powder mixing bucket, powder dispensing head, transmission device, lifting mechanism, etc. The powder dispensing head is the main component of the airflow dispensing machine to realize quantitative dispensing. The main body (dispensing tray) is a cylinder made of stainless steel, and there are eight equal single-row (or double-row) smooth circular holes with a certain diameter on the dispensing tray, that is, the dispensing holes. There is an adjustable powder attached isolation plug in the circular hole, and the powder device can be adjusted by adjusting the distance from the top of the plug and the cylindrical surface of the dispensing tray (ie the hole depth). The rear end of the sub-packing plate has the same number of holes as the powder-loading holes and is connected with the powder-loading holes. By means of the distribution plate, it is connected with vacuum and compressed air to realize the powder suction and discharge of the sub-packaging head in the intermittent rotation. The main factors affecting the powder packaging error are: the radial runout when the dispensing head rotates makes the dispensing surface unevenly divided; the beating of the rear end surface of the dispensing head causes leakage and collusion of vacuum and compressed air; the outer surface of the dispensing head is rough and uneven. The powder adheres to the powder; the inner surface of the dispensing hole is rough and adheres to the powder; the indexing of the dispensing hole is not allowed to make the powder unload outside the bottle mouth; the dispensing hole is not round, so that the powder is sucked away when the powder is loaded; the inner cavity of the dispensing head is eight sides The shape and axis are not perpendicular to cause gas leakage; the powder isolation plug is too loose or too dense; the compressed air pressure is unstable, causing the flow rate to be too large or too small; changes in the particle size, water content and fluidity of the powder cause changes in the powder density.