Matters needing attention when using deoxidizer packaging

Encapsulating deoxidizers in drug packaging can eliminate the need to add chemical additives such as mildew and antioxidants in the drug production process, thereby making drugs safer and beneficial to people's health. The following points should be noted when using deoxidizer packaging: 1. .Packaging materials and packaging containers, the materials used to encapsulate the deoxidizer packaging are required to have high air tightness, especially the isolation performance against oxygen, and the oxygen permeability at 25 ° C should be less than 20mL/(m2-24h -0.1MPa), mostly using composite films, such as KOPP/PE, KONy/PE, KPET/PE, PETP/AI/PE, etc., as well as metal, glass, ceramics and other packaging containers. For packaging containers with fixed volume and shape, attention should be paid to the effect of deoxygenation; 1/5 of the oxygen in normal air, after the oxygen is consumed, will generate negative pressure in the container and form a partial vacuum, so the packaging materials or containers are required to have a certain strength. In order to overcome the shrinkage of the package body due to the use of deoxidizers in flexible packaging, which affects the appearance, the deoxidizers that can generate carbon dioxide such as ascorbic acid can be used or combined with air-filled packaging to avoid this defect. 2. The deoxidizer must be well packaged before being subcontracted for use, and must not be in direct contact with the atmosphere. At the same time, it needs to be packaged and used quickly in the course of use, so as not to affect the use effect due to oxygen absorption. At present, iron-based deoxidizers used in pharmaceutical packaging are generally packaged with packaging materials with good air tightness, and should be used as they are opened. In the test table: after the deoxidizer is opened, it is placed in an environment with a temperature of 80% RH and a temperature of 25~30 ° C for 5 hours, and its deoxidization effect has no obvious effect. Therefore, the self-reactive iron-based deoxidizer must be used within 5hm after opening. The storage time of the dependent iron-based deoxidizer can be longer. 3. Pay attention to selecting the appropriate type of deoxidizer and deoxidizing effect. Whether the packaging of the deoxidizer can preserve the quality of the drug depends on the absorption capacity and absorption effect of the deoxidizer. Generally, the oxygen concentration of iron-based deoxidizers can be reduced to 0.35 within 4 hours of being sealed in the packaging. % below, it can reach 0.1% after 4h. If the quick-acting type and the alleviating-acting type deoxidizer are used together, it can not only achieve rapid deoxidation, but also maintain a long-term close to anaerobic state in the packaging, which can ensure the quality of the packaged drugs for a long time.